No. You will be required to confirm your log in whenever you
first log in on a device, after you log out of your account, or every three
months or so to re-verify your access on that device. Because there are
multiple ways to access information in Office 365 you may have to answer
multiple MFA prompts, especially on the first day. If you only ever access your
Office 365 account on a single device you will rarely have to provide an MFA
confirmation.
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